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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Trends Cell Biol. 2016 Feb 11;26(7):498–510. doi: 10.1016/j.tcb.2016.01.005

Figure 1. Key Figure: Variation in kinetochore composition in four eukaryotic taxa.

Figure 1

Kinetochores have been best-dissected biochemically in vertebrates (A) and budding yeast (B). These two kinetochores are remarkably similar in composition, with the most notable difference being the absence of CENP-M in yeast (grayed out) and the fungal-specific origin of the Dam1 complex, the functional counterpart of the Ska1 complex. However, the kinetochores in D. melanogaster (C) and holocentric Bombyx mori (D) are quite distinct from those in vertebrate and budding yeast. The conclusions that certain CCAN components are missing in both (C) and (D) are tempered by the possibility that rapid evolution might have impaired homology searches; these conclusions await further confirmation via proteomic or other experimental means.