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. Author manuscript; available in PMC: 2017 Jul 15.
Published in final edited form as: Dev Biol. 2015 Dec 31;415(2):278–295. doi: 10.1016/j.ydbio.2015.12.024

Figure 3. F1-9-13FP generates a null mutation in Memo1 that is subject to genetic background effects.

Figure 3

(A-D) An E14.5 control (A, C) or Memo1m1Will mutant (B, D) on the 129S1/SvlmJ genetic background showing the intact yolk-sac (A, B) or a lateral view of the embryo proper (C, D). (E-J) E18.5 mouse embryos, of the genotypes indicated, from a largely C57BL/6J background showing lateral views of the head (E, G, I) or ventral views of the secondary palate after the mandible has been removed (F, H, J). (K) Western blot analysis of protein isolated from E13.5 heads of wild-type, heterozygous, or homozygous F1-9-13FP mutants, and probed with an anti-MEMO1 antibody (anti-ACTIN used as a loading control, one embryo per lane).