Figure 6.

A selected slice from IR-UTE imaging of a cadaveric MS brain specimen shows loss of signal within the circled area (A); Histology of frontal subcortical WM from the subacute demyelinating lesion shown in the circle displays marked disruption of the normal histology with numerous reactive astrocytes (H&E) (B); GFAP IHC of the same region demonstrates the reactive, markedly hypertrophic astrocytosis (C); CD-68 staining demonstrates small numbers of perivascular macrophages in the same region as (B) and (C). Rare microglial cells are present in the acellular astroglial scar of the large, chronic demyelinated lesion in the occipital lobe (D, Inset); Another slice from IR-UTE imaging of the same MS brain specimen (E). This shows similar extensive myelin loss (F); A large chronic demylinated lesion in the occipital lobe of the same patient (circle, E) demonstrates the typical paucicellular astroglial scar with H&E staining (F); GFAP immunoreactivity shows the dense astrogial processes that have replaced normal structures in this demyelinated lesion (G); Vimentin immunoreactivity in the microvasculature of the both of the sampled brain regions demonstrates preservation of an epitope that is sensitive to fixation/processing (H). Higher magnification shows the delicate capillary labeling (H, Inset).