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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Pharmacol Res. 2016 May 6;110:10–24. doi: 10.1016/j.phrs.2016.04.028

Figure 13. The ARV drugs zidovudine (ZDV), emtricitabine (FTC), but not nevirapine (NVP), inhibit cloned GABAA receptor currents.

Figure 13

A, Representative traces showing whole cell currents activated by an EC30 concentration of GABA (5 μM) in HEK293 cells stably expressing α1β2γ2GABAA receptors. Efavirenz was co-applied with GABA for 10 sec. Note that ARV drug-induced action was rapid and reversible. B, Summary data of the modulatory effect induced by ZDV, FTC and NVP (30 μM). All currents were normalized to the GABA control response (GABA alone). *P < 0.05, paired t-test, compared to the control, n=6–8. Data are presented as means ± SEM.