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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Pharmacol Res. 2016 May 6;110:10–24. doi: 10.1016/j.phrs.2016.04.028

Figure 2. Efavirenz has low micromolar affinity for cloned metabotropic 5-HT2A, 5-HT2C and 5-HT6 receptors.

Figure 2

The affinity of efavirenz for each receptor was determined at equilibrium by concentration-dependent competition binding of radiolabeled receptors using rapid filtration. All data are presented as averaged values from multiple experiments ± SEM. A, The 5-HT2A receptor binds to efavirenz with an affinity (Ki) = 4.4 ± 0.43 μM and a pseudo Hill slope = −1.39 ± −0.18. B, The 5-HT2C receptor binds to efavirenz with an affinity (Ki) = 1.7 ± 0.28 μM and a pseudo Hill slope = −1.22 ± −0.18. C, The 5-HT6 receptor binds to efavirenz with an affinity (Ki) = 2.2 ± 0.27 μM and a pseudo Hill slope = −1.36 ± −0.14.