Table 1.
The protocol was for each subject to experience a total of 11 DBS settings.
| Testing order | DBS parameters tested | Assessments performed? |
|---|---|---|
| 1 | Clinically‐optimal settings (ClinDBS) | Yes |
| 2 | Stimulation turned off (DBS‐off) | Yes |
| Random | Biphasic pulses (BiphClinV) | Yes |
| – | Stimulation turned off (Washout) | No |
| Random | Biphasic pulses at 70% amplitude (Biph70%V) | Yes |
| – | Stimulation turned off (Washout) | No |
| Random | Irregular patterns (20%CVClinV) | Yes |
| – | Stimulation turned off (Washout) | No |
| Random | Irregular patterns at 70% amplitude (20%CV70%V) | Yes |
| – | Stimulation turned off (Washout) | No |
| Random | 50% shorter pulse widths (50%PWClinV) | Yes |
| – | Stimulation turned off (Washout) | No |
| Random | 50% shorter pulse widths at 150% amplitude (50%PW150%V) | Yes |
| 10 | Stimulation turned off (DBS‐off) | Yes |
| Random | Clinically‐optimal settings at 70% amplitude (70%ClinV) | Yes |
| 11 | Clinically‐optimal settings (ClinDBS) | Yes |
Clinically‐optimal settings and off‐stimulation were both tested at the beginning and end of the study. All other settings were tested in random order. Subjects were blinded to all settings and were only aware of a change.