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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Curr Opin Genet Dev. 2016 Jan 27;37:76–81. doi: 10.1016/j.gde.2015.12.003

Figure 1. Activities of pioneer factors.

Figure 1

(top) Pioneer factors can scan nucleosomal DNA for their target sites in silent chromatin. (middle) Increased residence time at targeted sites allows for cooperative interactions with other factors and more stable binding. (bottom) Binding of pioneer factors can lead to activated sequences (left) with open chromatin features (green flags) and a state of competence to be expressed or direct transcriptional activity, or repressed sequences (right) with closed chromatin features (red flags).