Table 2.

Multivariable-adjusted odds ratios (aOR) with 95% confidence intervals (CI) and p-for-trend for Parkinson’s disease (PD) risk by four age periods of self-reported overall moderate to vigorous physical activity^a.

Overall physical activity [MET-hour/week]b	PD/Control	aOR	95%CI	P-for-trendc
Lifetime Average
<47.8	107/84	1 (Reference)
47.8–93.0	75/79	0.68	0.43–1.07
93.0–180.0	73/79	0.68	0.43–1.07
≥180.0	81/78	0.56	0.34–0.92	0.05
18–24 years
<47.8	86/68	1 (Reference)
47.8–93.0	82/69	1.00	0.62–1.62
93.0–180.0	63/79	0.64	0.39–1.05
≥180.0	105/104	0.64	0.40–1.02	0.03
25–44 years
<47.8	111/93	1 (Reference)
47.8–93.0	67/73	0.78	0.49–1.22
93.0–180.0	53/62	0.73	0.45–1.19
≥180.0	105/92	0.82	0.53–1.28	0.33
45–64 years
<47.8	136/112	1 (Reference)
47.8–93.0	65/67	0.82	0.52–1.29
93.0–180.0	63/58	0.97	0.60–1.56
≥180.0	65/72	0.50	0.31–0.83	0.01
≥65 years
<47.8	145/112	1 (Reference)
47.8–93.0	51/48	0.89	0.54–1.46
93.0–180.0	24/35	0.50	0.27–0.92
≥180.0	18/21	0.65	0.31–1.37	0.08

^aLogistic regression models adjusted for age, gender, race, education, smoking, family history of PD, and residential and occupational pesticide exposures.

^bOverall Physical Activity (MET-h/wk) = 8*vigorous activity hour/week + 4*moderate activity hour/week; quartiles according to the average lifetime physical activity distribution in controls.

^cLinear trend was tested using the midpoint of each exposure category as a continuous variable in the regression model.