Figure 1.
Schematic diagram of the olfactory bulb circuit and expected pattern of synaptic activity elicited by each stimulation paradigm. Odor stimulation first activates synapses in the glomerular layer (GL). Electrical stimulation of the lateral olfactory tract (LOT) stimulates primarily synapses in the external plexiform layer (EPL) via antidromic activation of dendro-dendritic synapses in that layer. Electrical stimulation of the anterior commissure (AC) primarily stimulates synapses in the granule cell layer (GCL) via orthodromic activation of the AC fibers.