Table 1.

Overview of controversial publications on the role of the S1P₂ receptor in anaphylaxis, inflammation and cancer.

Anaphylaxis	Aggravation of anaphylaxis by S1P2	Attenuation of anaphylaxis by S1P2	Comments
	Jolly et al., 2004		S1P2 augments degranulation by Fc𝜀 receptor-I.
	Oskeritzian et al., 2010, 2015		S1P2-KO and JTE-013 reduce histamine release and attenuate severity of anaphylaxis.
		Olivera et al., 2010, 2013b	Severe hypotension and delayed plasma histamine clearance in S1P2-KO.
		Cui et al., 2013	Impaired survival in S1P2-KO mice challenged with antigen; only study to show vascular leak in S1P2-KO.
Inflammation	Pro-inflammatory role of S1P2	Anti-inflammatory role of S1P2	Comments
	Siehler et al., 2001; Blom et al., 2010; O’Sullivan et al., 2014		S1P2 activates NF-κB.
	Damirin et al., 2005; Li et al., 2009; Völzke et al., 2014		S1P2 induces COX-2 expression and PG synthesis.
	Skoura et al., 2011		S1P2-KO and JTE-013 reduce cytokine levels in LPS-treated mice.
		Stradner et al., 2013	S1P2 counteracts IL-1β in chondrocytes and cartilage.
	Sammani et al., 2010		S1P2-KO reduces bronchial leakage in LPS-induced lung injury.
	Roviezzo et al., 2007; Trifilieff et al., 2009; Fuerst et al., 2014		These studies show a principle role for S1P2 in allergic airway inflammation and constriction.
	Chiba et al., 2010		S1P2 is downregulated during sensitization, resulting in a loss of bronchoconstriction by S1P.
		Michaud et al., 2010	S1P2-KO increases number of peritoneal macrophages in thioglycollate-induced peritonitis.
	Roviezzo et al., 2011		JTE-013 reduces cell recruitment after subcutaneous injection of zymosan.
Cancer	Pro-cancerous role of S1P2	Anti-cancerous role of S1P2	Comments
		Cattoretti et al., 2009	B cell lymphoma in homozygous S1P2-KO mice.
		Yamaguchi et al., 2003	S1P2 overexpression and i.p. application of S1P reduce lung metastasis of implanted B16 melanoma cells.
		Du et al., 2010	Accelerated tumor growth in S1P2-KO mice.
	Young and van Brocklyn, 2007; Salas et al., 2011; Ponnusamy et al., 2012; Kawahara et al., 2013; Bi et al., 2014		Role for S1P2 in metastasis and/or chemoresistance of diverse tumors and/or tumor cell lines
	Miller et al., 2012; Yu et al., 2012; Adada et al., 2015		Activation of pro-cancerous signaling pathways by S1P2
	Li et al., 2015		Anti-tumor effect of an S1P2 antagonist

KO, knockout. This table does not claim to be exhaustive.