Table 2.
Hepcidin inducers and mimetics validated in vivo.
| Drug | Target | Reference |
|---|---|---|
| recombinant BMP6 | BMPRs | Corradini et al., 2010 |
| RNAi | Tmprss6 | Schmidt et al., 2013 |
| antisense oligonucleotides | Tmprss6 | Guo et al., 2013a |
| progesterone | PGRMC1 | Li et al., 2016 |
| LJPC-401 (hepcidin formulation) | FPN | La Jolla Pharmaceutical Company (http://www.lajollapharmaceutical.com) |
| PR65 (mini-hepcidin) | FPN | Ramos et al., 2012 |
| M009 (pro-M004) M004 (mini-hepcidin) | FPN | Casu et al., 2016 |
| M012 (mini-hepcidin) | FPN | Merganser Biotech (http://www.merganserbiotech.com) |
| PR73 (mini-hepcidin) | FPN | Arezes et al., 2015 |