Table 3.
Drug | Target | Reference |
---|---|---|
Tocilizumab (monoclonal IL-6 receptor Ab) | IL-6 receptor | Song et al., 2010 |
Siltuximab (monoclonal IL-6 Ab) | IL-6 | Casper et al., 2015 |
Curcumin | STAT3 | Jiao et al., 2009 |
AG490 (small molecule) | JAK2 | Zhang et al., 2011 |
Heparin | BMPs | Poli et al., 2011 |
glycol-split heparins | BMPs | Poli et al., 2014a |
highly sulfated heparins | BMPs | Poli et al., 2014b |
monoclonal HJV Ab | HJV | Abbvie (www.abbvie.com) |
sHJV.Fc | BMPs | Theurl et al., 2011 |
Dorsomorphin (small molecule) | type I BMPRs | Yu et al., 2008 |
LDN-193189 (small molecule) | type I BMPRs | Steinbicker et al., 2011 |
TP-0184 (small molecule) | ALK2 | Tolero Pharmaceuticals (www.toleropharma.com) |
1,25-dihydroxy-vitamin D | Vitamin D receptor | Bacchetta et al., 2014 |
17β–estradiol | estrogen-responsive promoter | Yang et al., 2012 |
Testosterone | EGFR | Latour et al., 2014 |
LY2787106 (monoclonal hepcidin Ab) | Hepcidin | Eli Lily and Company (www.lilly.com) |
PRS-808 (PEGylated anticalin) | Hepcidin | Pieris Pharmaceuticals Inc (www.pieris.com) |
NOX-H94 (PEGylated Spiegelmer) | Hepcidin | Schwoebel et al., 2013 NOXXON Pharma AG (www.noxxon.com) |
LY2928057 (monoclonal FPN Ab) | FPN | Witcher et al., 2013 Eli Lily and Company (www.lilly.com) |