Table 2.
Effect of S. aureus on IL-6 protein release by SM-HPBCs (white columns) and OM-HPBCs (gray columns).
| Acute infection | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IL-6 | 1 h | 3 h | 6 h | 9 h | ||||||||||||||||||||
| pg.mL−1 | Ctrl | 10:1 | 30:1 | Ctrl | 10:1 | 30:1 | Ctrl | 10:1 | 30:1 | Ctrl | 10:1 | 30:1 | ||||||||||||
| Max | 97 | 209 | 97 | 136 | 75 | 119 | 429 | 442 | 397 | 317 | 375 | 337 | 702 | 604 | 560 | 498 | 647 | 630 | 927 | 924 | 892 | 893 | 894 | 843 |
| Median | 22 | 5 | 14 | 12 | 15 | 7 | 99 | 73 | 72 | 61 | 111 | 57 | 254 | 153 | 328 | 231 | 347 | 242 | 671 | 717 | 671 | 718 | 667 | 702 |
| Min | – | – | – | – | – | – | 14 | 29 | 31 | 18 | 30 | 19 | 113 | 120 | 105 | 94 | 173 | 78 | 471 | 571 | 442 | 527 | 419 | 459 |
| Persistent infection | ||||||||||||||||||||||||
| IL-6 | 1 h | 9 h | 24 h | 48 h | ||||||||||||||||||||
| pg.mL−1 | Ctrl | 10:1 | 30:1 | Ctrl | 10:1 | 30:1 | Ctrl | 10:1 | 30:1 | Ctrl | 10:1 | 30:1 | ||||||||||||
| Max | 2097 | 1947 | 1688 | 2136 | 1983 | 1939 | 3324 | 3242 | 2670 | 3212 | 3250 | 3152 | 4523 | 4852 | 3943 | 5095 | 4778 | 5023 | 5011 | 6250 | 4284 | 5773 | 4778 | 6155 |
| Median | 726 | 895 | 714 | 781 | 683 | 750 | 2445 | 2540 | 1682 | 2409 | 1918 | 2213 | 3712 | 3422 | 3068 | 3047 | 3315 | 3047 | 3939 | 4066 | 3170 | 3739 | 3358 | 3630 |
| Min | 24 | – | 105 | 17 | – | – | 583 | 82 | 521 | 73 | 424 | 54 | 779 | 85 | 738 | 121 | 612 | 82 | 833 | 94 | 750 | 119 | 810 | 114 |
Cells were exposed to viable S. aureus (MOI of 10:1 and 30:1) for 1, 3, 6, and 9 h in acute infection and for 1, 9, 24, and 48 h in persistent infection. Data are presented as minimal value, median value, and maximal value from four independent donors (– means undetermined).