Table 1.

Comparison of non-invasive neuroimaging methods for acquiring connectome data.

Modality and substrate	Advantage	Disadvantage
MRI: anatomy	• High resolution images of brain structure	• Only provides anatomical information
DTI: water diffusion	• High resolution images of fiber tracts	• Only provides information on structural connectivity
fMRI: blood oxygen consumption	• High spatial resolution • Able to localize function • Measures resting state and task-based functional connectivity	• Relatively slower timing resolution • Only measures lower frequency oscillations
MEG: synchronous firing of neuronal populations	• Millisecond temporal resolution • Broadband measurement of spectral data • Relatively good spatial localization when used with a good source reconstruction algorithm • Measures resting state and task-based functional connectivity	• Uncertain as to sensitivity for n = 1 measurements and clinical decisions