Table 3.

Phenotype of initial MBP-deficient mouse models.

Genotype	Phenotype	Reference
Mecp2 null	Rett syndrome-like phenotype. Between 3 and 5 weeks: uncoordinated gait, reduced spontaneous movement, hind limb clasping, irregular breathing, misaligned jaws, uneven wearing of teeth, reduced brain weight, and neuronal cell size. Between 6 and 12 weeks: rapid weight loss and death.	Chen et al., 2001; Guy et al., 2001
Mbd1 null	Viable and fertile. Impaired spatial learning, decreased neurogenesis, reduced long-term potentiation, decreased genomic stability.	Zhao et al., 2003
Mbd2 null	Viable, fertile. Maternal nurturing defects: reduced litter size and weight of pups.	Hendrich et al., 2001
Mbd3 null	Early embryonic lethality	Hendrich et al., 2001
Mbd4 null	Viable and fertile. Increased number of C:G to T:A transitions at CpG sites.	Millar et al., 2002
Kaiso null	Viable and fertile. Reduced tumorigenesis	Prokhortchouk et al., 2006
Np95 null	Early gestational lethality. Developmental arrest shortly after gastrulation.	Sharif et al., 2007
Np97 null	Phenotype not described.	Li et al., 2013