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Observed pharmacokinetic parameters of sulfamethoxazole (800 mg) calculated using a one-compartment model with lag time
| Parametera | Median (IQR) |
|---|---|
| AUC (mg/liter · h)b | 566.6 (360.8–658.1) |
| CL (liters/h) | 1.34 (1.19–2.04) |
| V (liters) | 14.53 (11.82–16.82) |
| V/BW (liter/kg) | 0.23 (0.19–0.30) |
| kel (h−1) | 0.09 (0.08–0.14) |
| Ka (h−1) | 1.34 (0.72–4.49) |
| Lag time (h) | 0.46 (0.17–0.63) |
| F | 1 (fixed) |
BW, body weight.
Calculated using the trapezium rule.
