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Pharmacokinetic parameters of the population model
| Parameter | Mean (95% CI)a | SD (95% CI) | Shrinkage |
|---|---|---|---|
| CLm (liters/h/1.85 m2) | 1.57 (1.01–2.04) | 3.71 (0.26–3.46) | −0.8 |
| V (liters · kg lean body mass−1) | 0.30 (0.25–0.39) | 0.05 (0.02–0.11) | 0.20 |
| fr | 0.02 (0.00–0.10) | 0.13 (0.00–0.33) | 0.08 |
| Ktr_po (h−1) | 2.26 (1.21–6.36) | 1.05 (0.28–2.57) | −0.02 |
| N_po | 2.12 (1.00–5.84) | 0.73 (0.17–3.44) | 0.51 |
The 95% confidence intervals (CI) were obtained by bootstrap analysis.
