FIG 2.

POA concentration-time profiles in plasma and lung lesions (A) and in ELF (B) after administration of the indicated dose of PZA to infected C3HeB/FeJ mice. Open symbols and dotted lines represent intralesional concentrations (A), and solid shapes indicate concentrations in plasma (A) or in ELF (B). Data are plotted as means and were averaged for two experiments in panel A and in exploded view in panel B to show the difference observed. Horizontal dotted lines represent the lower limit of quantification.