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Survival (a) and bacterial load in the lungs (b) of mice that received different antibiotics. Beginning at 2 h after infection, mice were injected peritoneally with minocycline (50 mg/kg), colistin (10 mg/kg), or both antibiotics every 12 h. For calculation of the bacterial load in lungs, the mice were sacrificed at 24 h after infection. MIN, minocycline; CS, colistin.
