TABLE 2.

Cumulative frequencies of all mutations among Mycobacterium tuberculosis specimens resistant or susceptible to rifampin

Gene	Observed mutation(s) by gene location	No. of RIFr specimens sequenced	No. of RIFs specimens sequenced	No. of RIFr specimens with mutation	No. of RIFs specimens with mutation	Frequency of mutation among RIFr specimens (%)a	Frequency of mutation among RIFs specimens (%)b
rpoB	531TTG	450	266	360	0	80.0	0.0
	516GTC	427	262	22	1	5.2	0.4
	526GAC	450	266	9	0	2.0	0.0
	531TGG	450	266	9	0	2.0	0.0
	533CCG	450	266	6	2	1.3	0.8
	526TAC	450	266	5	1	1.1	0.4
	516TAC	427	262	3	3	0.7	1.1
	526AAC	450	266	3	1	0.7	0.4
	526TGC	450	266	3	0	0.7	0.0
	515ATA and 526AAC	389	222	1	0	0.3	0.0
	511CCG	427	262	1	2	0.2	0.8
	511CGG and 516TAC	427	262	1	0	0.2	0.0
	513AAA	427	262	1	0	0.2	0.0
	526CGC	450	266	1	0	0.2	0.0
	526CTC	450	266	1	0	0.2	0.0
	526GGC	450	266	1	0	0.2	0.0
rpoB with no mutations	Wild type	389	222	14	212	3.6	95.5

^aFrequency of mutation among RIF^r specimens was calculated as the number of RIF^r specimens with the mutation/number of RIF^r specimens sequenced.

^bFrequency of mutation among RIF^s specimens was calculated as the number of RIF^s specimens with the mutation/number of RIF^s specimens sequenced.