TABLE 3.
Cumulative frequencies of all mutations among Mycobacterium tuberculosis specimens resistant or susceptible to fluoroquinolones
| Gene | Observed mutation(s) by gene location | No. of FQr specimens sequenced | No. of FQs specimens sequenced | No. of FQr specimens with mutation | No. of FQs specimens with mutation | Frequency of mutation among FQr specimens (%)a | Frequency of mutation among FQs specimens (%)b |
|---|---|---|---|---|---|---|---|
| gyrA | 94GGC and 95ACC | 278 | 467 | 117 | 1 | 42.1 | 0.2 |
| 90GTG and 95ACC | 278 | 467 | 62 | 2 | 22.3 | 0.4 | |
| 94GCC and 95ACC | 278 | 467 | 23 | 0 | 8.3 | 0.0 | |
| 91CCG and 95ACC | 278 | 467 | 15 | 0 | 5.4 | 0.0 | |
| 94AAC and 95ACC | 278 | 467 | 11 | 0 | 4.0 | 0.0 | |
| 94TAC and 95ACC | 278 | 467 | 10 | 0 | 3.6 | 0.0 | |
| 90GTG | 278 | 467 | 8 | 0 | 2.9 | 0.0 | |
| 94GGC | 278 | 467 | 4 | 0 | 1.4 | 0.0 | |
| 88TGC and 95ACC | 278 | 467 | 3 | 0 | 1.1 | 0.0 | |
| 94CAC and 95ACC | 278 | 467 | 2 | 0 | 0.7 | 0.0 | |
| 88GCC | 278 | 467 | 1 | 0 | 0.4 | 0.0 | |
| 90GTG, 91CCG and 95ACC | 278 | 467 | 1 | 0 | 0.4 | 0.0 | |
| 94AAC | 278 | 467 | 1 | 0 | 0.4 | 0.0 | |
| 88GCC and 95ACC | 278 | 467 | 1 | 0 | 0.4 | 0.0 | |
| 91CCG | 278 | 467 | 1 | 0 | 0.4 | 0.0 | |
| 95ACC | 278 | 467 | 17 | 427 | 6.1 | 91.4 | |
| gyrA with no mutations | Wild type | 278 | 467 | 1 | 37 | 0.4 | 7.9 |
a
Frequency of mutation among FQr specimens was calculated as the number of FQr specimens with the mutation/number of FQr specimens sequenced.
b
Frequency of mutation among FQs specimens was calculated as the number of FQs specimens with the mutation/number of FQs specimens sequenced.