. 2016 Jun 20;60(7):3994–4004. doi: 10.1128/AAC.00222-16

TABLE 4.

Cumulative frequencies of all mutations among Mycobacterium tuberculosis specimens resistant or susceptible to amikacin, kanamycin, and/or capreomycin

Gene	Mutation	INJ	No. of INJ^r specimens sequenced	No. of INJ^s specimens sequenced	No. of INJ^r specimens with mutation	No. of INJ^s specimens with mutation	Frequency of mutation among INJ^r specimens (%)^a	Frequency of mutation among INJ^s specimens (%)^b
rrs only	1401G	AMK	73	728	61	5	83.6	0.7
		KAN	121	680	61	5	50.4	0.7
		CAP	70	731	59	7	84.3	1.0
eis only	−12C/T	AMK	78	793	1	67	1.3	8.4
		KAN	141	730	37	31	26.2	4.2
		CAP	75	796	1	67	1.3	8.4
	−10G/A	AMK	78	793	0	6	0.0	0.8
		KAN	141	730	5	1	3.5	0.1
		CAP	75	796	0	6	0.0	0.8
	−14C/T	AMK	78	793	1	6	1.3	0.8
		KAN	141	730	3	4	2.1	0.5
		CAP	75	796	0	7	0.0	0.9
	−37G/T	AMK	78	793	0	4	0.0	0.5
		KAN	141	730	3	1	2.1	0.1
		CAP	75	796	0	4	0.0	0.5
	−10G/C	AMK	78	793	0	3	0.0	0.4
		KAN	141	730	0	3	0.0	0.4
		CAP	75	796	0	3	0.0	0.4
	−15C/G	AMK	78	793	0	1	0.0	0.1
		KAN	141	730	1	0	0.7	0.0
		CAP	75	796	0	1	0.0	0.1
rrs with no mutations	Wild type	AMK	73	728	12	723	16.4	99.3
		KAN	121	680	60	675	49.6	99.3
		CAP	70	731	11	724	15.7	99.0
rrs or eis with no mutations	Wild type	AMK	71	714	9	631	12.7	88.4
		KAN	119	666	18	622	15.1	93.4
		CAP	68	717	9	631	13.2	88.0

Frequency of mutation among injectable (INJ)-resistant (INJ^r) specimens was calculated as the number of injectable-resistant specimens with the mutation/number of injectable-resistant specimens sequenced.

Frequency of mutation among injectable-sensitive (INJ^s) specimens was calculated as the number of injectable-sensitive specimens with the mutation/number of injectable-sensitive specimens sequenced.