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Inhibition of hemozoin formation by BHs. Compounds 5a to 5f inhibit hemozoin formation and favor the accumulation of free heme in the parasite. Hemozoin formation was measured in the presence or absence of BHs as described in Materials and Methods. Values are normalized by using the upper and lower plateaus of the best-fit curve as 100 and 0% inhibitions, respectively, of hemozoin formation. Each experiment was performed in triplicate. The data are shown as means ± the SD.
