TABLE 2.

Heme-binding activity of benzothiazole hydrazones^a

Compound	Heme binding (mean KD [μM] ± SD)
5a	9.69 ± 1.8
5b	9.23 ± 2.3
5c	11.19 ± 4.1
5d	5.58 ± 1.2
5e	3.03 ± 0.9
5f	1.17 ± 0.8

^aDifferential optical Soret spectroscopy was performed in order to determine benzothiazole hydrazone compound-heme interaction, and the K_D values were calculated from 1/λ_max(nm) versus 1/[compounds 5a to 5f] (Fig. 3). K_D, dissociation constant for compound-heme interaction. All experiments were performed in triplicate.