TABLE 4.
Four-day parasite-suppressive activity of compound 5f against an MDR P. yoelii strain in mice
| Compound | Dose (mg/kg) | Mean % ± SDa |
|
|---|---|---|---|
| Parasitemia | Suppression | ||
| Control | 58.65 ± 0.3 | 0 | |
| 5f | 10 | 41.91 ± 1.1* | 28.48 ± 1.26 |
| 25 | 24.73 ± 0.8* | 57.79 ± 4.43 | |
| 50 | 11.32 ± 1.3* | 80.69 ± 3.59 | |
| α/β arteether | 50 | 0** | 100 |
*, P < 0.05; **, P < 0.005 (compared to the control).