TABLE 1.
Numbers of rabbits per treatment group and deaths and densities of organisms in tissuea
| Treatment group | No. of rabbits (no. of deaths) | Mean density of organisms (log10 CFU/g) ± SD |
||
|---|---|---|---|---|
| Vegetationb | Spleenc | Kidneyd | ||
| Control | 6 (NA) | 8.11 ± 0.67 | 6.53 ± 0.43 | 6.91 ± 0.57 |
| Dapto | 8 (4) | 8.48 ± 1.52 | 5.95 ± 0.90 | 5.51 ± 1.40 |
| Ctrx | 8 (4) | 8.00 ± 1.42 | 6.17 ± 2.19 | 5.57 ± 2.10 |
| Erta | 8 (6) | 7.23 ± 1.64 | 4.99 ± 0.96 | 5.01 ± 1.40 |
| Dapto + Ctrx | 8 (2) | 6.94 ± 1.93 | 3.40 ± 1.87 | 3.68 ± 2.39 |
| Dapto + Erta | 8 (1) | 6.62 ± 1.16 | 3.49 ± 1.55 | 2.56 ± 1.37 |
Dapto, daptomycin; Ctrx, ceftriaxone; Erta, ertapenem; NA, not applicable.
P > 0.1 for the control group versus the daptomycin treatment group, P = 0.052 for the ceftriaxone group versus the daptomycin-ceftriaxone group, and P > 0.1 for the ertapenem group versus the daptomycin-ertapenem group.
P > 0.1 for the control group versus the daptomycin treatment group, P = 0.014 for the daptomycin group versus the daptomycin-ceftriaxone group, and P = 0.066 for the ertapenem group versus the daptomycin-ertapenem group.
P < 0.033 for the control group versus the daptomycin treatment group, P > 0.1 for the daptomycin group versus the daptomycin-ceftriaxone group, and P = 0.010 for the ertapenem group versus the daptomycin-ertapenem group.