TABLE 2.
Plasma drug concentrations and half-lives of antibiotics used for treatment
| Antibiotic | Mean concn (μg/ml) ± SD (range) (no. of samples)a |
Half-life (h) | |
|---|---|---|---|
| 1 h after dosing | Trough | ||
| Daptomycin | 140 ± 28 (103–184) (7) | 1.4 ± 0.6 (0.7–2.4) (8) | 3.3 |
| Ceftriaxone | 300 ± 76 (209–340) (5) | 2.8 ± 3.1 (0.7–8.3) (5) | 3.4 |
| Ertapenem | 214 ± 40 (176–269) (4) | 0.4 ± 0.2 (0.1–0.6) (4) | 2.5 |
a
One-hour samples were obtained on day 1 or 2. Trough samples were obtained at the time of sacrifice, ∼24 h after the last dose.