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. 2016 Jun 20;60(7):4297–4309. doi: 10.1128/AAC.02123-15

FIG 1.

FIG 1

A suboptimal dose of Bz is efficient to control parasite burden, and PTX therapy does not disrupt the efficacy of Bz. (A) Chronically T. cruzi-infected C57BL/6 mice were treated daily (120 to 150 dpi) with Veh, PTX (20 mg/kg in saline, intraperitoneally), or a suboptimal dose of Bz (one-quarter dose of 25 mg/kg in water, by gavage) alone or combined with PTX (Bz plus PTX) and analyzed at 150 dpi. (B) Parasitemia levels. (C) Group data for qPCR detection of T. cruzi kDNA (330 bp). In each experiment, groups consisted of 3 NI controls and 4 or 5 randomly sorted infected mice per experimental group. Mice administered therapies with PTX, Bz, or Bz plus PTX were compared with Veh-injected mice (#, P < 0.05; ##, P < 0.01). Bz-plus-PTX-treated mice were compared with PTX-treated mice (§, P < 0.05). Low-high bar graphs show lines at mean, minimum, and maximum values.