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. 2016 Jun 20;60(7):4063–4072. doi: 10.1128/AAC.03001-15

TABLE 1.

Stability of P60.4Ac in the three formulations stored for 3 months at 4°C and ambient temperaturea

Length of storage (mo) Peptide yield (%)
Softisan cream
Cetomacrogol cream
Hypromellose gel
4°C 15–25°C 4°C 15–25°C 4°C 15–25°C
0 90.3 96.6 95.0 95.5 99.3 101.6
1 96.7 91.0 90.6 69.4 99.3 102.4
3 95.3 93.8 66.5 47.3 93.2 90.0
a

Peptide yields from the Softisan cream, Cetomacrogol cream, and hypromellose gel containing 0.5% (wt/wt) P60.4Ac were measured immediately before and after a storage period of 1 and 3 months at 4°C and at ambient temperature (15 to 25°C). The peptide content of the creams and gel was calculated using a standard curve constructed with a range of concentrations of P60.4Ac in PBS. No degradation products of P60.4Ac were found. Results are means from two independent experiments.