TABLE 1.
Stability of P60.4Ac in the three formulations stored for 3 months at 4°C and ambient temperaturea
Length of storage (mo) | Peptide yield (%) |
|||||
---|---|---|---|---|---|---|
Softisan cream |
Cetomacrogol cream |
Hypromellose gel |
||||
4°C | 15–25°C | 4°C | 15–25°C | 4°C | 15–25°C | |
0 | 90.3 | 96.6 | 95.0 | 95.5 | 99.3 | 101.6 |
1 | 96.7 | 91.0 | 90.6 | 69.4 | 99.3 | 102.4 |
3 | 95.3 | 93.8 | 66.5 | 47.3 | 93.2 | 90.0 |
Peptide yields from the Softisan cream, Cetomacrogol cream, and hypromellose gel containing 0.5% (wt/wt) P60.4Ac were measured immediately before and after a storage period of 1 and 3 months at 4°C and at ambient temperature (15 to 25°C). The peptide content of the creams and gel was calculated using a standard curve constructed with a range of concentrations of P60.4Ac in PBS. No degradation products of P60.4Ac were found. Results are means from two independent experiments.