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Inhibition of E. coli topoisomerase I relaxation activity by scaffold-ranking library 2229. (A) Scaffold library mixture 2229 inhibits E. coli topoisomerase I but not DNA gyrase. Lanes 1, control reaction mixture with no enzyme added; lanes 2, DMF control; lanes 3 to 6, scaffold library mixture 2229 at concentrations of 100, 50, 25, and 12.5 μg/ml, respectively. (B) Structures of the six polyamine scaffolds.
