FIG 2.
Total population of ATCC 19606 in response to polymyxin B regimens in the hollow-fiber infection model. The following regimens for polymyxin B were simulated: regimen 1, polymyxin B non-loading dose (1.43 mg/kg q12h, generating an fAUC0–24 of 28.9 mg/liter · h across the first day and an fAUCss of 35.9 mg · h/liter at steady state); regimen 2, polymyxin B with loading dose (2.22 mg/kg for 1 dose followed by 1.43 mg/kg q12h starting 12 h later, with an fAUC0–24 of 35.9 mg · h/liter across each day); regimen 3, polymyxin B front-loading dose (3.33 mg/kg for 1 dose followed by 1.43 mg/kg q12h starting 12 h later, with an fAUC0–24 of 48.2 mg · h/liter across the first day and an fAUCss of 35.9 mg · h/liter at steady state); regimen 4, polymyxin B burst (5.53 mg/kg for 1 dose followed by no subsequent doses, with an fAUC0–24 of 60.4 mg · h/liter); and regimen 5, polymyxin B supraburst (18.4 mg/kg for 1 dose followed by no subsequent doses, fAUC0–24 of 202.5 mg · h/liter).