TABLE 2.

IC₅₀ and selectivity index of MPA and MPA derivatives 2 and 4 against T. b. brucei and T. evansi

Compound	IC50 (μM)a for:				Selectivity indexa,b for:
	T. congolense	T. b. brucei	T. evansi	MDBK cell	T. congolense	T. b. brucei	T. evansi
1 (MPA)	0.10 ± 0.04	0.62 ± 0.05	0.61 ± 0.002	0.52 ± 0.12	5.14	0.84	0.85
2	0.56 ± 0.21	>2.5	>2.5	1.4 ± 0.18	2.62	ND	ND
4	0.16 ± 0.04	1.26 ± 0.009	1.38 ± 0.10	0.84 ± 0.21	5.10	0.67	0.61

^aAll values were calculated from 3 independent experiments and expressed as means ± SD.

^bMean IC₅₀ of MDBK cells/mean IC₅₀ of trypanosomes. ND, not determined.