TABLE 3.
Effects of guanosine and xanthine on parasite proliferation under IMPDH inhibition by MPA and N-(2,3,5-triazolyl) mycophenolic amide (compound 4)
| Guanosine or xanthine supplementation (μM) | IC50 (μM)a with: |
|||
|---|---|---|---|---|
| Guanosine for compound: |
Xanthine for compound: |
|||
| 1 (MPA) | 4 | 1 (MPA) | 4 | |
| 250 | >5.0 | >5.0 | 0.09 ± 0.001 | 0.21 ± 0.01 |
| 50 | 0.29 ± 0.19 | 0.50 ± 0.31 | 0.09 ± 0.003 | 0.22 ± 0.01 |
| 0 | 0.07 ± 0.006 | 0.13 ± 0.02 | 0.09 ± 0.004 | 0.22 ± 0.02 |
a
All values were calculated from 3 independent experiments and are shown as means ± SD.