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. 2016 Jun 20;60(7):3956–3969. doi: 10.1128/AAC.02560-15

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Copyright © 2016 Nowicka-Sans et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 6 — Evaluation of Gag/Pr libraries derived from subtype B and C clinical isolates for BMS-955176 sensitivity in a multiple-cycle assay. (A) Multiple-cycle assay comparing responses of panels of all subtype B (closed circles) and C (open inverted triangles) gag/pr recombinant viruses for BMS-955176 sensitivity. Polymorphic subtype B (open triangles) is defined as a single change at Gag position 362, 369, 370, or 371 from WT subtype B (open circles). The median EC₅₀ for WT subtype B is 2.5 nM; bars are interquartiles of medians. (B) Statistics for panel A; FC-EC₅₀ = EC₅₀ test assay/median value of EC₅₀ for library of 51 WT (no changes to Gag 362, 369, 370, or 371) gag/pr recombinant viruses. *, 36/87 total subtype B viruses had key a single polymorphism in Gag at position 362, 369, 370, or 371. Each experimental point is the mean of triplicate determinations.