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Concentration-time profiles for colistin base (A) and polymyxin B base (B to D) of simulated (t1/2 = 11.6 h, Css,avg = 3 mg/liter) clinically relevant polymyxin dosage regimens. (A) Gradual rise of colistin (as seen in patients following CMS administration); (B) polymyxin B, 1-h infusion every 12 hours with no loading dose; (C) polymyxin B, 1-h infusion every 12 hours with a conventional loading dose; (D) polymyxin B, 1-h infusion every 12 hours with an augmented loading dose.
