TABLE 1.

MICs of S-649266 and other antibacterial agents against clinical strains with various β-lactamases

Species	β-Lactamase	No. of isolates	MIC range (μg/ml)
			S-649266a	Ceftazidime	Cefepime	Meropenem
Pseudomonas aeruginosa	IMP-1	3	0.016 to 0.5	>256	256 to >256	128 to >256
	VIM-2	3	0.25 to 1	128 to 256	64 to 128	32 to 256
Klebsiella pneumoniae	NDM-1	4	0.5 to 2	>256	32 to >256	64 to 256
	KPC-2 or KPC-3	4	0.06 to 0.5	256 to >256	64 to >256	16 to 256
Escherichia coli	NDM-1	2	0.5 to 1	>256	64 to >256	16 to 32
Stenotrophomonas maltophilia	L1	3	0.125 to 0.5	128 to 256	64 to 128	128 to 256
Acinetobacter baumannii	OXA-23	5	0.03 to 0.5	128 to >256	16 to 128	16 to 32

^aSupplemented with 20 μM human apotransferrin.