TABLE 3.

Hydrolysis velocity of S-649266 and other antibacterial agents by NDM-1

Antibacterial agent	Velocity at substrate concn ofa:
	100 μM		200 μM
	Hydrolysis velocity (μM/s)	Relative velocity	Hydrolysis velocity (μM/s)	Relative velocity
S-649266	0.092 ± 0.0059	18	0.23 ± 0.018	32
Meropenem	0.50 ± 0.014	100	0.72 ± 0.012	100
Ceftazidime	1.0 ± 0.015	210	1.5 ± 0.024	210
Cefepime	0.46 ± 0.028	91	0.68 ± 0.0092	94

^aEach hydrolysis velocity is the mean ± SD of three different measurements. Relative velocity was calculated by assuming the hydrolysis velocity of meropenem to be 100.