Figure 7.

Regulatory States Co-segregate with Evolutionary V_H Clans

(A) Evolutionary organization of V gene families in clans.

(B) Relationship between regulatory states and evolutionary V_H clans.

(C) Geographical position of actively recombining V_H genes overlapping the three states (top) and V_H clans (bottom) across the mouse V_H region. Clans 2 and 3 are colored the same (red) to reflect their overlap in state classification (A). The V_H3609 family is colored green to denote its outlier status as an E state, but clan 2, family. Co-switching of the A and E states with clans 2+3 and 1, respectively, can be seen for the middle families.

See also Figure S6D.