TABLE 2.

Physiological Parameters Used for the Rat PBPK Model

Parameter	Value	Source
BW (g)- assume 1 g = 1 ml	250.0	Nong et al. (2008)
Cardiac Output (Q_CO; ml/min)	83.0	Brown et al. (1997)
Tissue volume (as a fraction of BW)
Kidney (V_Kid)	0.0073	Brown et al. (1997)
Liver (V_Liv)	0.0366	Brown et al. (1997)
GI tract (V_GI)	0.0269	Brown et al. (1997)
Rest of body (V_Rap)	0.0137	Brown et al. (1997); remaining tissues
Muscle (V_Mus)	0.404	Brown et al. (1997)
Skin (V_Skin)	0.190	Brown et al. (1997)
Slowly perfused tissues (V_Slow)-for bone	0.050	Brown et al. (1997)
Adipose (V_Fat)	0.064	Brown et al. (1997)
Brain (V_Brn)	0.0057	Brown et al. (1997)
Thyroid (V_Thy)	0.00005	Brown et al. (1997)
Blood (V_Bld)	0.070	Brown et al. (1997)
Blood Flow (as a Fraction of Cardiac Output)
Kidney (Q_Kid)	0.141	Brown et al. (1997)
Liver (Q_Liv)	0.183	Brown et al. (1997)
Rest of body (Q_Rap)	Difference	Q_CO—blood flow of all other tissues
Muscle (Q_Mus)	0.278	Brown et al. (1997)
Skin (Q_Skin)	0.058	Brown et al. (1997)
Slowly perfused tissues (Q_Slow)- for bone	0.122	Brown et al. (1997)
Adipose (Q_Fat)	0.070	Brown et al. (1997)
Brain (Q_Brn)	0.020	Brown et al. (1997)
Thyroid (Q_Thy)	0.00271	Huffman and Hedge (1986)
Portal vein (Q_PV)	0.153	Brown et al. (1997)
Hepatic artery (Q_HA)	Difference	Q_Liv–Q_PV