TABLE 3.

Physiological Parameters Used for the Human PBPK Model

Parameter	Value	Source
BW(g)- assume 1 g = 1 ml	70000.0	Brown et al. (1997)
Cardiac Output (Q_CO; ml/min)	5200.0	Brown et al. (1997)
Tissue Volume (as a Fraction of BW)
Kidney (V_Kid)	0.0040	Brown et al. (1997)
Liver (V_Liv)	0.026	Brown et al. (1997)
GI tract (V_GI)	0.0171	Brown et al. (1997)
Rest of body (V_Rap)	0.0493	Brown et al. (1997); remaining tissues
Muscle (V_Mus)- for females	0.290	Brown et al. (1997)
Skin (V_Skin)- for females	0.031	Brown et al. (1997)
Slowly perfused tissues (V_Slow)- for bone	0.049	Brown et al. (1997)
Adipose (V_Fat)- for females	0.327	Brown et al. (1997)
Brain (V_Brn)	0.020	Brown et al. (1997)
Thyroid (V_Thy)	0.0003	Brown et al. (1997)
Blood (V_Bld)	0.0714	Brown et al. (1997)
Blood Flow (as a Fraction of Cardiac Output)
Kidney (Q_Kid)	0.175	Brown et al. (1997)
Liver (Q_Liv)	0.227	Brown et al. (1997)
Rest of body (Q_Rap)	Difference	Q_CO—blood flow of all other tissues
Muscle (Q_Mus)	0.191	Brown et al. (1997)
Skin (Q_Skin)	0.058	Brown et al. (1997)
Slowly perfused tissues (Q_Slow)- for bone	0.042	Brown et al. (1997)
Adipose (Q_Fat)	0.085	Brown et al. (1997)
Brain (Q_Brn)	0.114	Brown et al. (1997)
Thyroid (Q_Thy)	0.016	Brown et al. (1997)
Portal vein (Q_PV)	0.181	Brown et al. (1997)
Hepatic artery (Q_HA)	Difference	Q_Liv - Q_PV