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. 2016 Jun 21;2:16011. doi: 10.1038/celldisc.2016.11

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The loss of Arrdc1 or Arrdc4 decreases EV release in MEFs. (A) EVs were isolated from WT and Arrdc1 ^−/− MEFs and the protein concentration was normalized to number of live cells. Knockout of Arrdc1 ^−/− significantly attenuated the release of EVs. Data are mean±s.e.m.; n=3 biological replicates with three technical replicates each; ****P<0.0001. (B) The protein concentration of EVs released from Arrdc4 ^−/− MEFs is significantly reduced compared with WT MEFs. Data are mean±s.e.m.; n=3 biological replicates with three technical replicates each; ***P<0.001.