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. 2016 Jun 21;6:27251. doi: 10.1038/srep27251

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(a) The relative risks of response to HBV vaccine between adults age ≥60 and adults age <60. (b) The relative risks of response to HBV vaccine between male adults and female adults. (c) The relative risks of response to HBV vaccine between male adults and female adults grouped by study design. Comparing with female adults, The RRs suggest declined response to HBV vaccine among male adults both in cohort and RCT studies. (d) The relative risks of response to HBV vaccine between BMI ≥25 adults and BMI <25 adults.