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. 2016 Jun 21;6:28329. doi: 10.1038/srep28329

Figure 7. miR-106a/b attenuates breast cancer stem-like cell properties by inhibition of STAT3 and HIF-1α.

Figure 7

(A) SUM102 cells were tranfected with miR-106a or miR-106b and STAT3 siRNA or HIF-1α in the present of CM from the co-cultured with fibroblasts and cancer cells. Sphere formation was assayed. (B) SUM102 cells were tranfected with miR-106a or miR-106b and STAT3 siRNA or HIF-1α in the present of CM from the co-cultured with fibroblasts and cancer cells. The second sphere formation was assayed. (C) SUM102 cells were tranfected with miR-106a or miR-106b and STAT3 siRNA or HIF-1α in the present of CM from the co-cultured with fibroblasts and cancer cells. Stem cell markers were examined by western blotting. (D) Protein bands from (C) were quanlified. The data presented are shown as means ± s.d. collected from three independent experiments. *p < 0.05, **p < 0.01.