Table.
Reference | Study Population | Cancer Treatment | Time of Sample Collection | Sample Type | Findings |
---|---|---|---|---|---|
Belazi et al. (2004) | 39 patients with head and neck cancer | RT | During | Swabs (lesion) | Candida albicans, Candida glabrata, Candida krusei, Candida tropicalis, and Candida kefyr were most common |
Napenas et al. (2010) | 9 patients with breast cancer | CT | Before/during | Buccal mucosa swabs | The total number of bacterial species per patient increased and a shift to a more complex oral bacterial was found during CTGemella haemolysans and Streptococcus mitis were the most predominant species |
Sonalika et al. (2012) | 61 patients with squamous cell carcinoma and 72 controls | RT | Before/after | Saliva | Significant increase in Candida spp. was promoted by RT Increase in Escherichia coli, Pseudomonas aeruginosa, Enterobacter sp., and Klebsiella pneumonia contributed to exacerbation of mucositis |
Panghal et al. (2012) | 186 patients with squamous cell carcinoma | RT or CT or chemoRT | During | Oral swab blood | P. aeruginosa was isolated from the blood of RT patients and K. pneumonia was isolated from the oral cavity of CT patients.Staphylococcus aureus and Staphylococcus epidermidis were observed in the blood of CT and chemoRT patients and in the oral cavity of patients undergoing RTC. albicans was the most significant oral cavity pathogen in RT and chemoRT casesAnaerobic species such as Parvimonasmicra, Fusobacterium nucleatum, Treponema denticola, C. glabrata, and C. kefyr were also associated with ulcerative OM |
Laheij et al. (2012) | 49 patients with hematological malignancies | HSCT | Before/during | Oral rinse | Porphyromonas gingivalis was a prediction factor for OM |
Hu et al. (2013) | 8 patients with head and neck cancer | RT | Before/during | Dental plaque | 4 phyla (Actinobacteria, Bacteroidetes, Firmecutes, and Proteobacteteria) and 11 genera (Streptococcus, Actinomyces, Veillonella, Capnocytophaga, Derxia, Neisseria, Rothia, Prevotella, Granulicatella, Luteococcus, and Gemella) were found in all subjects |
Ames et al. (2012) | 45 patients who underwent allogeneic transplantation | HSCT | Before/after | Saliva, dental plaque, buccal and tongue brush | Many common bacterial genera such as Streptococcus, Veillonella, Gemella, Granulicatella, and Campylobacter were identified as being present before and after transplantation |
Chavan et al. (2013) | 11 children with hematological malignancies | HSCT | After | Blood, cerebrospinal fluid, tissue |
Rothia mucilaginosa infections was clinically significant in neutropenic children undergoing HSCT |
chemoRT, chemoradiation; CT, chemotherapy; HSCT, hematopoietic stem cell transplant; OM, oral mucositis; RT, radiation therapy.