Table 2.
Median plasma level of inflammatory mediators in the 3 outcome groups
| Favorable outcome 6Ma | Unfavorable outcome 6Ma | Brain death | p value | |
|---|---|---|---|---|
| IL-6 | 75.08 (31.81; 104.76) | 169.95 (79.17; 188.3) | 750 (602; 817) | <0.0001 |
| IL-1β | 0.66 (0.1; 1.05) | 1.04 (0.6; 5.78) | 1.32 (1.1; 1.97) | 0.179 |
| IL-1ra | 66.92 (34.68; 226.97) | 82.02 (70; 384.13) | 532.66 (399; 2078.5) | 0.078 |
| IL-2 | 0.8 (0.8; 0.8) | 0.8 (0.8; 0.8) | 0.8 (0.8; 29.5) | 0.041 |
| IL-4 | 0.21 (0.01; 1.32) | 0.6 (0.42; 5.31) | 0.93 (0.8; 1.34) | 0.304 |
| IL-5 | 0.85 (0.13; 5.24) | 1.14 (0.28; 15.36) | 0.5 (0.29; 0.62) | 0.415 |
| IL-7 | 9.27 (1.38; 31.41) | 45.4 (7.23; 141.17) | 58.98 (16.25; 92.5) | 0.215 |
| IL-8 | 19.39 (3.99; 39.64) | 60.29 (39; 104.58) | 125.55 (37.02; 129) | 0.013 |
| IL-9 | 12.13 (2.35; 20.13) | 32.91 (28; 46.86) | 23.68 (20.5; 48.26) | 0.022 |
| IL-10 | 11.52 (1.57; 20.14) | 20 (7.83; 57.02) | 39.47 (12.37; 108.5) | 0.029 |
| IL-12 | 5.64 (0.81; 22.2) | 11.82 (5.33; 42.48) | 20.15 (17; 109.5) | 0.043 |
| IL-13 | 2.97 (0.62; 5.27) | 7.4 (1.92; 11.27) | 12.06 (5.78; 30) | 0.047 |
| IL-15 | 1.05 (0.06; 4.6) | 0.06 (0.06; 6.16) | 22.75 (3.7; 44.9) | 0.001 |
| IL-17 | 0.9 (0.9; 9.58) | 49.06 (0.9; 75.33) | 67.84 (28; 77.42) | 0.162 |
| Eotaxin | 0.35 (0.35; 18.45) | 19 (0.35; 29.31) | 24.49 (10.5; 34.42) | 0.094 |
| basic FGF | 3 (3; 24.45) | 48.73 (3; 66.79) | 49.61 (49.49; 131) | 0.053 |
| GCSF | 50.95 (8.99; 138.65) | 156.61 (107.5; 368.77) | 483.17 (165; 491.86) | 0.012 |
| GMCSF | 48 (2.29; 78.14) | 39.18 (0.21; 91.61) | 99.55 (83.84; 113) | 0.084 |
| IFNγ | 4.15 (1.08; 25.73) | 14.97 (11.99; 110.33) | 25 (24.74; 29.08) | 0.230 |
| IP-10 | 111.06 (29; 256.19) | 248.22 (215.09; 459.34) | 2081.5 (528.43; 2232.08) | <0.0001 |
| MCP1 | 162.16 (44.12; 307.83) | 196.04 (77.78; 657.25) | 690.82 (600; 2210) | 0.001 |
| MIP1α | 1.5 (0.05; 2.33) | 3.07 (1.2; 6.49) | 3.71 (0.05; 11) | 0.209 |
| PDGFbb | 141.57 (58.58; 229.67) | 271.36 (195.11; 372.25) | 104.64 (93.1; 210.46) | 0.324 |
| MIP1β | 87.27 (55.98; 134.88) | 123.05 (98; 133.01) | 416 (275.42; 594) | 0.001 |
| RANTES | 5193.61 (1952.35; 8553.06) | 8903.57 (4098.28; 11442.69) | 3570.05 (2309.71; 3831.31) | 0.564 |
| TNF-RI | 1252.27 (522.38; 1568.18) | 1320.45 (970.33; 1513.64) | 1957 (1543.13; 2679) | 0.394 |
| TNF-RII | 2190 (730; 4723.08) | 4161.9 (3707.69; 5368.54) | 5678 (4919; 6564.78) | 0.021 |
| TNFα | 8 (5.58; 50.59) | 5.5 (3.9; 93.05) | 9.78 (8.12; 18.45) | 0.262 |
| VEGF | 6.04 (0.08; 27.12) | 29.79 (8.12; 42.22) | 60.22 (34.28; 322) | 0.002 |
| IL6/IL10 | 57 (30.39; 324.61) | 59.24 (39.89; 104.28) | 277.07 (126.7; 1598.89) | 0.765 |
| IL1ra/IL1β | 7.92 (3.66; 19.53) | 8.9 (3.77; 22.4) | 27.11 (5; 32.29) | 0.064 |
aAt 6 months. Values are median (IQR). IQR interquartile range. Significant correlations are reported in italics