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. 2016 Jun 21;17:293. doi: 10.1186/s13063-016-1423-0

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© Schouten et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schematic representation of the study. In Part 1 patients with advanced disease will be enrolled to be administered carboplatin and olaparib in two 3-weekly cycles followed by olaparib monotherapy until dose limiting toxicity or progressive disease. The maximum tolerable dose will be determined