Table 5.
Predictors of disability and outcome on univariate analysis in patients with tuberculous meningitis
| Characteristics | BI≤12 (n=50) | BI>12 (n=91) | P value | Odds Ratio | 95 % Confidence interval | |
|---|---|---|---|---|---|---|
| Lower bound | Upper bound | |||||
| Age | 29.320±11.881 | 29.989±13.322 | .768 | −3.797 | 5.135 | |
| Duration of illness | 42.140±21.204 | 53.560±27.761 | .013 | 2.495 | 20.345 | |
| Gender | 22(44 %) | 54(59.3 %) | .080 | .538 | .268 | 1.082 |
| HIV | ||||||
| Fever | 49(98 %) | 89(97.8 %) | .938 | 1.101 | .097 | 12.453 |
| Headache | 44(88 %) | 87(95.6 %) | .092 | .337 | .090 | 1.257 |
| Seizure | 15(30.0 %) | 33(36.3 %) | .453 | .753 | .359 | 1.580 |
| Altered Sensorium | 31(62.0 %) | 13(14.3 %) | <.001 | 9.789 | 4.316 | 22.206 |
| Decreased vision | 16(32.0 %) | 19(20.9 %) | .144 | 1.783 | .817 | 3.891 |
| Hemiparesis | 9(18.0 %) | 14(15.4 %) | .688 | 1.207 | .482 | 3.027 |
| Paraparesis | 6(12.0 %) | 6(6.6 %) | .271 | 1.932 | .588 | 6.342 |
| Meningeal signs | 44(88.0 %) | 81(89 %) | .856 | .905 | .308 | 2.657 |
| Lymphadenopathy | 4(8.0 %) | 9(9.9 %) | .711 | .792 | .231 | 2.716 |
| Diplopia | 19(38.0 %) | 40(44.0 %) | .493 | .821 | .402 | 1.675 |
| Cranial Nerve involvement | 28(56.0 %) | 52(57.1 %) | .896 | .955 | .476 | 1.914 |
| Papilloedema | 18(36.0 %) | 37(40.7 %) | .587 | .821 | .402 | 1.675 |
| Hydrocephalus | 40(80.0 %) | 13(14.3 %) | <.001 | 24.0 | 9.677 | 59.520 |
| Basal Exudates | 12(24.0 %) | 26(28.6 %) | .558 | .789 | .357 | 1.744 |
| Tuberculoma | 22(44.0 %) | 29(31.9 %) | .151 | 1.680 | .825 | 3.422 |
| Infarct | 9(18.0 %) | 16(17.6 %) | .950 | 1.029 | .418 | 2.533 |
| Optochiasmatic arachnoiditis | 7(14.0 %) | 14(15.4 %) | .825 | .895 | .336 | 2.388 |
| Spinal arachnoiditis | 6(12.0 %) | 6(6.6 %) | .271 | 1.932 | .588 | 6.342 |
| Stage-III TBM | 31(62.0 %) | 13(14.3 % | <.001 | 9.789 | 4.316 | 22.206 |
| Definite TBM | 23(46.0 %) | 31(34.1 %) | .163 | |||
| Paradoxical reaction | 12(24.0 %) | 32(35.2 %) | .171 | .582 | .267 | 1.268 |
| CSF Cells | 159.340 | 206.242 | .152 | −17.474 | 111.277 | |
| CSF protein | 256.772 | 252.019 | .953 | −163.99 | 154.488 | |
| CSF sugar | 35.112 | 35.422 | .925 | −6.153 | 6.773 | |
CSF cerebrospinal fluid, HIV human immunodeficiency virus, BI Barthel index, TBM tuberculous meningitis
Note: Statistically significant P-values are depicted in italics