Fig. 2. Ursodeoxycholic acid changes plasma and liver parameters and is not hepatotoxic. (A) Plasma ALT, AST, and lipid profiles (B) Liver triglyceride (TG) and cholesterol. Results are expressed as the mean±SEM. Statistical analysis was performed by the two-way analysis of variance, using gender and drug as factors. No significant differences among groups were observed for ALT and AST. A statistical difference due to gender (but not drug) was evident for total cholesterol and LDL cholesterol. For the remaining parameters, a significant interaction was observed between gender and drug, demonstrating that the difference of gender results in altered response to UDCA. Bars with different letters are significantly different, P < 0.05. (C) Hematoxylin and eosin staining of liver sections show reduced hepatic adiposity after UDCA treatment in both male and female mice. n = 3 mice/group for males, and 6 mice/group for females.
