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. 2016 Jun 20;7:11914. doi: 10.1038/ncomms11914

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(a) IF on bladders from untreated control 8-month-old mouse. (b) Widespread carcinoma in situ (CIS) in the bladder of a 6-month-old mouse treated with BBN for 4 months, showing remarkable KRT14^pos cell population expansion, and extensive KRT14 and KRT5 colocalisation. (c) Invasive urothelial carcinoma (UC) in the bladder of an 8-month-old mouse treated with BBN for 6 months, showing extensive colocalisation of KRT14 and KRT5. (d-i) Krt14^CreERT2/+;R26^tdTomato/+ mice treated with tamoxifen before BBN treatment for 4 (d,f) or 6 months (e,g-i) showing variable histological abnormalities and cytokeratin profile. Stars designate the bladder lumen. Scale bars, 100 μm.