Fig. 2.

Changes in the function and viability of dopaminergic neurons after exposure to WT FL-α-Syn or A29-V40 peptide, the corresponding A30P mutants, or LPS. a Changes in the ability of rat neuron-glia cultures to take up ³H-labeled DA after exposure to WT α-Syn peptides A19-A30 or A29-V40, their corresponding mutants A19-A30 (A30P) or A29-V40 (A30P), or LPS. b Changes in the number of TH-positive neurons in rat neuron-glia cultures after exposure to WT α-Syn peptides A19-A30 or A29-V40, their corresponding mutants A19-A30 (A30P) or A29-V40 (A30P), or LPS. n = 5–6; *P < 0.05, **P < 0.01, and ***P < 0.001, compared with the basal controls; ^# P < 0.05, compared as indicated. c Representative images, which were captured by a ×10 objective, showing TH-positive neurons in rat neuron-glia cultures treated with various stimuli